Bono and co had talks last year with the makers of the game, MTV Games and Electronic Arts, but a deal wasn't agreed because of what bassist Adam Clayton called "compromises" they wouldn't agree to.
Now, since the release of 'The Beatles: Rock Band', Clayton has told USA Today that the U2 game could still be on the way.
"We definitely would like to be in there," he said. "But we felt some of the compromises weren't what we wanted. That could change. I love the idea that that's where people are getting music and we'd love to be in that world. We'll figure something out."
The bassist confirmed that it was seeing The Beatles' game that renewed his enthusiasm for a possible U2 version.
"What The Beatles have done, where the animation is much more representative of them, is what we’re interested in, rather than the one-size-fits-all animation," he said. "We didn't want to be caricatured."